O curativo compressivo usado em queimadura de tórax influencia na mecânica do sistema respiratório? / Does the compressive dressing made in burning of thorax influence in the mechanics of the respiratory system?

Introdução: O paciente com queimadura em tórax apresenta restrição torácica pela queimadura e pela dor, levando a uma diminuição de força muscular respiratória. A utilização de curativos cirúrgicos e curativos no leito é de extrema importância para pacientes queimados, pois são utilizados para prevenção de infecção e inflamação da área queimada, porém estes curativos podem contribuir com esta restrição da afecção, levando à formação de atelectasias e outras complicações respiratórias. Objetivo: Verificar a influência do curativo torácico no sistema respiratório. Método: Foram realizadas medidas da Pimax e Pemax, capacidade vital, volume corrente, frequência respiratória, volume minuto e peak flow em 10 indivíduos do sexo feminino, com média de idade média de 23 anos (18-26), saudáveis, sem restrições respiratórias, em três etapas, com e sem curativo oclusivo em tórax e repetidas as mensurações 15 minutos após a colocação do curativo. Resultados: Houve diminuição da força muscular respiratória, do volume corrente, capacidade vital e aumento da frequência respiratória após a colocação do curativo oclusivo em tórax. Conclusão: O uso do curativo compressivo de tórax influenciou nas medidas de mecânica respiratória de indivíduos normais, levando à diminuição da força muscular inspiratória e expiratória, queda no fluxo expiratório e na capacidade vital.

Background: The patient with burning in thorax presents a thorax restriction for burning and for pain, leading to a reduction of respiratory muscular force. The use of surgical dressings and dressings in the stream bed is of extreme importance for burnt patients, therefore infection prevention of and inflammation of the burnt area are used for, however these dressings can contribute with this restriction of the pathology leading the respiratory formation of atelectasis and other complications. Objective: To verify the influence of the thorax dressing in the respiratory system. Methods: They had been carried through measured of the Pimax and Pemax, vital capacity, current volume, respiratory frequency, volume minute and peak flow in 10 individuals of the feminine sex, with average of age average of 23 years (18-26), healthful, without respiratory restrictions, in three stages, with and without occlusive dressing in thorax and repeated the measurement 15 minutes after rank of the dressing. Results: It had a reduction of the respiratory muscular force, of the current volume, vital capacity and increase of the respiratory frequency after the rank of the occlusive dressing in thorax. Conclusion: The use of the compressive dressing of thorax influenced in the measures of respiratory mechanics of normal individuals, taking the reduction of the inspiratory and expiratory muscular force, fall in the expiratory flow and the vital capacity.

Chimeric virus-like particles of the human papillomavirus type 16 (HVP 16) as a prophylactic and therapeutic vaccine

Infection by certain human papillomaviruses (HPV), most notably HPV types 16 and 18, is the mejor risk factor cervical cancer. Worldwide, this disease represents the second most frequent malignant tumor in women; thus, there is urgent need for efficient therapy and prevention. The natural history of cervical cancer and its precursors (cervical intraepithelial neoplasias), as well as animal experiments, strogly suggest that immune system controls both the primary infection (by neutralizing antibodies directed against the major structural protein L1) and the progression o the disease (via cytotoxic T cell specific for the viral oncoproteins expressed in transformed cells, e.g., E7). By the expression of an HPV 16 L1E7 fusion proteins, we have generated chimeric virus-like particles (CVLP). Immunization of mice with CVLPs induces neutralizing antibodies directed against L1 virus-like particles (devoid of the E7 portion) and E7-specific t cells as measured in vitro. Vaccinated animals are protected against tumor growth followings inoculation of syngeneic HPV 16-transformed cells. In addition, we observed a therapeutic effect of vaccination on pre-existing tumors. This data allowed us to concelude that CVLPs are suitable for prevention and therapy of HPV infection. A vaccine based on HPV 16 L1E7 CVLPs is currently under development